SGF 5000 Research Facts

1. Fibroblast Growth Factor Modulates HIV Coreceptor CXCR4 Expression by Neural Cells
Virginia J. Sanders,1 Ian P. Everall,3 Robert W. Johnson,1 Eliezer Masliah,2* and HNRC Group
This study demonstrates that fibroblast growth factor FGF (found in SGF-5000)can decrease CXCR4 levels in neuronal cells and increase receptor levels in astroglial cells, both in a dose- and time-dependent manner.

2. Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells
Nicola J. Jordan,1 George Kolios,1 Stewart E. Abbot,1 Michael A. Sinai,2 Darren A. Thompson,2 Kalliopi Petraki,3 and John Westwick1
To determine whether chemokine receptors are expressed in human colonic epithelium, HT-29 cells were examined by RT-PCR for the expression of the chemokine receptors for lymphotactin, fractalkine, CCR1-10, and CXCR1-5.

3. Dendritic cells and the control of immunity
Jacques Banchereau & Ralph M. Steinman
Immunology has long been focused on antigens and lymphocytes, but the mere presence of these two parties does not always lead to immunity.